Table 1.
Werner syndrome diagnostic criteria.
Figure 1.
Cumulative percentage of malignancies (%) by age at diagnosis in Japan-resident WS cases (1965–2009) versus Osaka population (1998–2002).
*Osaka prefecture neoplasm-specific population incidence data were categorized by gender and aggregated into 5-year age groups. Hence we were able to calculate only a median age range from Osaka population data, in contrast to the exact median age we were able to calculate for our WS patient cohort.
Table 2.
Werner syndrome diagnostic confidence categories.
Table 3.
Werner syndrome study population.
Figure 2.
Spectrum of neoplasia in Werner syndrome patients.
Distribution of neoplasms by histopathologic type and frequency among study population subjects included in Table S1.
Table 4.
Standardized proportionate incidence ratios (SPIRs) for malignancies in Japan-resident Werner syndrome patients.
Table 5.
Standardized incidence ratios (SIRs) for malignancies in Japan-resident Werner syndrome patients.***
Table 6.
Median ages and age ranges for cancer in Werner syndrome versus other cancer predisposition syndromes.