Figure 1.
Chemical structures of ketamine, methoxetamine, phencyclidine and analogues.
Table 1.
Molecular Targets Profiled.
Figure 2.
Mesh plot summarizing pharmacology of 3 novel PCP analogues.
Shown in three dimensional mesh plot format are the pKi values of the three novel PCP analogues (3-MeO-PCE, 3-MeO-phencyclidine and 4-MeO-phencyclidine; 1, 2 and 3 respectively) against a panel of 56 molecular targets.
Figure 3.
Representative Ki determination for methoxetamine in an NMDA receptor assay compared with reference compound MK-801 (dizocilpine).
Shown are results from a typical experiment wherein methoxetamine Ki values were determined (Ki = 337+/−76 nM; N = 3 separate determinations of this type) and MK-801 (Ki = 5.7+/−0.57 nM; N = 3 separate determinations of this type).
Table 2.
Representative pKi values for ketamine, PCP and analogues.