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Figure 1.

Study flowchart.

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Table 1.

Baseline features associated with 90-day mortality.

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Table 2.

Organ support during ICU stay and Laboratorial data at ICU discharge related to 90-days outcome.

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Figure 2.

Plot versus criterion value curves for the CRP/albumin ratio and mortality at 90 days (Panel A) and for CRP versus 90-day mortality (Panel B).

The X-axis shows the CRP/albumin ratio (Panel A) and serum CRP levels in mg/L (Panel B). The Y-axis shows the percentage. The solid and dashed lines indicate sensitivity and specificity with 95% confidence intervals, respectively.

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Figure 3.

Kaplan-Meier curves showing the 90-day survival of septic patients after discharge from the intensive care unit.

Solid line, CRP/albumin ratio <2 group; dashed line, CRP/albumin ratio >2 group; triangles, censored patients.

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Table 3.

Evaluation of potentially useful markers of 90-day mortality after discharge.

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Table 4.

Multivariate models to predict 90-day mortality after ICU discharge.

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Figure 4.

Model of the probability of mortality at 90 days after ICU discharge.

The probability of death at 90 days after ICU discharge is depicted using a multivariate logistic model. In A and C, the model is depicted versus age and in B and D versus SOFA score. The models A and B include age, SOFA score, chronic comorbidities, hemoglobin levels and ICU LOS. The models C and D include all variables cited above in addition to the CRP/albumin ratio. The black and gray solid lines indicate the calculated probability of death for dead and alive patients, respectively. For young and less severe patients, the model CRP/albumin ratio (C and D) could differentiate better between survivors and non-survivors than the model without biomarkers. However, as age and SOFA score increase, both models presented similar differences between survivors and non-survivors. The lines were fitted using a loess smooth function.

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