Figure 1.
Flow chart of search strategy.
Table 1.
Main Characteristics and Results of the Eligible Studies.
Table 2.
Main Characteristics and Results of the Eligible Studies (cont.d).
Figure 2.
Meta-analysis (Forest plot) of the eligible studies evaluating the association between COX-2 overexpression and survival.
Each study was shown by the name of the lead author and the HR with 95% CI. The summary HR and 95% CI were also shown (overall). (A) The 18 studies assessing COX-2 overexpression with OS in all population, (B) The 7 studies assessing COX-2 overexpression with OS with multivariate analysis, (C) The 9 studies assessing COX-2 overexpression with OS in Asian population, (D) The 9 studies assessing COX-2 overexpression with OS in non-Asian population, (E) The 9 studies assessing COX-2 overexpression with DFS in all population, (F) The 5 studies assessing COX-2 overexpression with DFS in Asian population. (G) The 4 studies assessing COX-2 overexpression with DFS in non-Asian population.
Table 3.
Meta-analysis. HR value in subgroup analysis according to outcomes of interest, and population.
Figure 3.
Funnel plot for studies included in the meta-analysis.
Plots are arranged as follows: (A) COX-2 overexpression with OS, (B) COX-2 overexpression with OS by multivariate analysis, (C) COX-2 overexpression with OS in Asian population, (D) COX-2 overexpression with OS in non-Asian population, (E) COX-2 overexpression with DFS, (F) COX-2 overexpression with DFS in Asian population, and (G) COX-2 overexpression with DFS in non-Asian population.