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Table 1.

Criteria and definitions for study selection and data analysis.

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Figure 1.

Flowchart of study selection.

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Table 2.

Categories of vaccinations used and rationale for grouping.

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Table 3.

Characteristics and findings of all studies included (n = 72).

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Figure 2.

Forest plot for short-term response for vaccines from category A (tetanus, diphtheria, polio), B (hepatitis A and B), D (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitides), E (varicella, mumps, measles, rubella) and F (tick-borne encephalitis and rabies).

All article types are included. Numbers in brackets refer to legend in Table 3.

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Figure 3.

Forest plot for short-term response for vaccine category C (influenza) against influenza H1N1.

All type of trials which assessed specific response to H1N1 are included. Numbers in brackets refer to legend in Table 3.

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Figure 4.

Forest plot for short-term response for vaccine category C (influenza) against influenza H3N2.

All type of trials which assessed specific response to H3N2 are included. Numbers in brackets refer to legend in Table 3.

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Figure 5.

Forest plot for short-term response for vaccine category C (influenza) against influenza B.

All type of trials which assessed specific response to B are included. Numbers in brackets refer to legend in Table 3.

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Figure 6.

Meta-analysis for case-control studies using the Mantel-Haenszel fixed effects method (M–H) and the DerSimonian and Laird random effects (D+L) method for response to influenza H1N1.

Numbers in brackets refer to legend in Table 3.

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Figure 7.

Meta-analysis for case-control studies using the Mantel-Haenszel fixed effects method (M–H) and the DerSimonian and Laird random effects (D+L) method for response to influenza H3N2.

Numbers in brackets refer to legend in Table 3.

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Figure 8.

Meta-analysis for case-control studies using the Mantel-Haenszel fixed effects method (M–H) and the DerSimonian and Laird random effects (D+L) method for response to influenza B.

Numbers in brackets refer to legend in Table 3.

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Figure 9.

Forest plot for studies investigating both short-term response (grey bars and numbers) and long-term response (black bars and numbers).

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Figure 9 Expand