Figure 1.
Gene Expression Subtypes in Head and Neck Squamous Cell Carcinoma.
Heatmaps of the expression values of the 840 classifier genes (A) and select genes associated with HNSCC (B) for each of the expression subtypes. Validation heatmaps of the centroid-based distances between the centroids of the expression subtypes in the current study and those from Chung et al. (C) and the LUSC subtypes of Wilkerson et al. (D).
Table 1.
Clinical Data.
Figure 2.
Copy Number Gains and Losses in the Expression Subtypes.
Plots of the mean copy number values in the HNSCC expression subtypes after smoothing and outlier removal, both genome-wide (A) and for specific chromosomes or regions of interest (B).
Figure 3.
Average Gene Expression and Copy Number by Expression Subtype.
Mean gene-specific copy number and gene expression values in the HNSCC expression subtypes and normal tonsil samples (NL) for genes in the 3q amplicon.
Table 2.
DNA Copy Number Events Involving Canonical Cancer Genes.
Figure 4.
Recurrence-Free Survival in Expression Subtypes.
Kaplan-Meier plots and Log-Rank Test p-values comparing recurrence-free survival times in all expression subtypes (A), HPV+ vs. HPV− subjects (B), all expression subtypes in HPV− subjects (C), and AT vs. non-AT in HPV− subjects (D). Statistical significance was assessed using the Log Rank Test.