Table 1.
Scale for quality assessment.
Figure 1.
Flow diagram of included studies for this meta-analysis.
Table 2.
Characteristics of eligible studies.
Figure 2.
Forest plots of MTHFR gene polymorphisms and HCC risk. A
Forest plots of MTHFR C677T polymorphism and HCC risk in subgroup analysis by ethnicity using a random-effect model (contrast TT vs. CC); B Forest plots of MTHFR A1298C polymorphism and HCC risk in subgroup analysis by ethnicity using a fixed-effect model (CC vs. AA).
Table 3.
Meta-analysis of the MTHFR gene polymorphisms on HCC risk.
Figure 3.
Galbraith plots of C677T polymorphism and HCC risk in different contrast models.
A The studies of Ventura et al., D’Amico et al. were outliers in the contrast TT vs. CC. B The studies of Ventura et al., D’Amico et al. were outliers in the recessive model TT vs. CT+CC. C The studies of Ventura et al., D’Amico et al. were outliers in the dominant model TT+CT vs. CC.
Figure 4.
Galbraith plots of A1298C polymorphism and HCC risk in Asians, The study of Yang et al. was the outlier in recessive model CC vs. AC+AA.
Figure 5.
Funnel plot analysis to detect publication bias.
Each point represents a separate study for the indicated association. A Funnel plot for contrast TT vs. CC of C677T polymorphism in overall analysis; B Funnel plot for allele contrast CC vs. AA of A1298C polymorphism in overall analysis.