Table 1.
Subject group characteristics.
Figure 1.
Region showing an increased glucose metabolism in frontotemporal lobar degeneration compared to control subjects in center 1 after normalization to cerebral global mean.
A significance threshold of p<0.000001 family-wise error corrected at voxel level was applied. This region was used as reference cluster for the subsequent intensity normalization.
Figure 2.
Regions showing a significant decrease in glucose metabolism in frontotemporal lobar degeneration compared to control subjects in center 1 (left) and 2 (right) after intensity normalization to different reference regions, in particular primary sensorimotor cortex (SMC), cerebral global mean (CGM), cerebellum (CBL), and reference cluster (RC).
Table 2.
Hypometabolism in patients with frontotemporal degeneration after intensity normalization to different reference regions.
Figure 3.
Regions showing an increase in glucose metabolism in frontotemporal lobar degeneration compared to control subjects in center 1 after intensity normalization to different reference regions, in particular primary sensorimotor cortex (SMC), cerebral global mean (CGM), cerebellum (CBL), and reference cluster (RC).
Figure 4.
Accuracies, sensitivities and specificities are displayed for each type of intensity normalization.
Accuracies, sensitivities and specificities were obtained using mean uptake values extracted from the cerebellar cluster (center 1 (a), center 2 (b)) and from the overlap of all clusters detected at center 1 (center 1 (c), center 2 (d)) for differentiation between frontotemporal lobar degeneration patients and control subjects using logistic regressions. Mean values and standard deviations (error bars) obtained after 5000 permutations using split-half cross-validation are displayed. SMC primary sensorimotor cortex, CBL cerebellum, CGM cerebral global mean, RC reference cluster.