Table 1.
Study population characteristics of African American women from the PAGE Study.
Figure 1.
Regional Association Plots for Age at Menarche in African American women in the PAGE Study.
Locus Zoom plots for selected gene regions in age at menarche analysis. Vertical axis is –log10 of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with age at natural menopause in 1,860 African American women from the PAGE Study. Approximate linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r2 legend in each plot. (A) Locus Zoom plot for the CYP19A1 region, with rs10519297 the most significant SNP in the region. (B) Locus Zoom plot for the FTO region; rs2689243 was the most significant SNP in the plot region. (C) LIN28B region Locus Zoom plot; rs408949 was the most significant SNP in the plot region. (D) Locus Zoom plot of the CYP1B1 region; rs13391045 was the most significant SNP in the plot region.
Table 2.
Comparison of GWAS-identified AM variants in African American women from the PAGE Study.
Figure 2.
Regional Association Plots for Age at Natural Menopause in African American women in the PAGE Study.
Locus Zoom plots for selected gene regions in age at natural menopause analysis. Vertical axis is the –log10 of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with age at natural menopause in 1,860 African American women from the PAGE Study. Linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r2 legend in each plot. (A) Locus Zoom plot for the APOE region, with rs78916952 the most significant SNP in the region. (B) Locus Zoom plot for the MCM8 region; rs237688 is the most significant SNP in the plot region. (C) FSHB region Locus Zoom plot; rs605765 is the most significant SNP in the plot region. (D) Locus Zoom plot of the BRSK1 region with rs11672111 as the most significant SNP in the plot region.
Table 3.
Comparison of GWAS-identified ANM variants in African American women in PAGE Study.
Table 4.
ANM Discovery–SNPs associated with age at natural menopause (ANM) in African American women from the PAGE Study.