Figure 1.
Abbreviated decay scheme of 225Ac.
225Ac emits 4 α particles in the process of decaying to the long-lived 209Bi.
Figure 2.
Schematic of gold coated lanthanide phosphate NP.
The α emitter is loaded in the {La0.5Gd0.5}PO4 core, the GdPO4 layer(s) increase retention of the decay chain daughters, and the Au shell facilitates attachment of targeting agents.
Figure 3.
TEM image of {La0.5Gd0.5}PO4 core NPs.
Figure 4.
TEM of a characteristic cluster of NPs.
EELS analysis indicates the presence of La, Gd, and Au in all particles in the cluster.
Table 1.
Growth of NP diameter as a function of shell addition as measured by TEM.
Table 2.
Dynamic light scattering of NPs in 18 MΩ water.
Figure 5.
MAb 201b antibody conjugation to multi-layered NPs.
Figure 6.
Biodistribution of NPs following tail vein injection in mice at 1 hour (n = 3).
Figure 7.
SPECT/CT images 1 hour post-injection of 80 µCi of {La0.5Gd0.5}(225Ac)PO4@GdPO4@Au-mAb-201b.