Table 1.
Table 1 demonstrates the clinical demographics for the patient population studied in this manuscript.
Figure 1.
Regions with significantly higher uptake in Tc-99m HMPAO during the ictal state compared with the interictal state, based on paired sample t-test.
Figure 2.
State dependent connectivity matrices.
The upper panel displays the connectivity matrices illustrating the strength of connectivity across 84 regions of interest. The numbering of regions is equivalent to Table S1. Regions 1 to 42 represent the hemisphere contralateral to seizure onset, while 43 to 84 represent the homologous regions (1–43, 2–44, and so on) on the ipsilateral side. Each matrix entry represents the correlation coefficient “R” between each pair of regions. The lower panel demonstrates the percent change (ictal/interictal) and the difference between states.
Figure 3.
The anatomical distribution of positive (purple) and negative (cyan) links during the ictal and interictal states.
A change in the number and distribution of positive and negative links can be observed in the ictal state compared with the interictal state. In the ictal state, a higher number of positive links is observed over the ipsilateral temporal lobe, with a concurrent reduction of positive links in extra-temporal regions.
Figure 4.
Statistical differences between the ictal and interictal state.
These differences are displayed in a matrix of p-values. The row and column distribution is equivalent to the connectivity matrices displayed in previous figures (x-axis and y-axis ranging from regions 1 to 84). However, the upper triangular matrix represents the location were there was a significant ictal>interictal connectivity, while the lower triangular matrix represents interictal>ictal. These results are corrected for significant comparisons. The figure also highlights clusters of significant links with a legend to explain the corresponding anatomical location.
Figure 5.
Changes in nodal graph properties in the ictal state compared with the interictal state.
For all measures, nodes demonstrating at least 25% of change between states are shown. The nodes are displayed according to their stereotaxic location, and red represents a change ictal>interictal, and blue interictal>ictal. The size of the node is relatively proportional to the size of positive changes.
Figure 6.
The average connectivity between pairs of regions, generated by bootstrapping the regional tracer uptake in each individual 10,000 times.
Figure 7.
Average global network metrics.
The global network metrics (y-axis) from the bootstrapped data are displayed across fixed density thresholds (x-axis) for binarized matrices. Statistically significant differences are highlighted with a red star.