Table 1.
Clinical details of MwoA patients and healthy controls.
Figure 1.
ICN group and difference maps.
A. Spatial group maps of three important pain-related ICNs (DMN, CEN and SN) covering all participants (including the HC and MwoA patients), with the CEN split into a right and left lateralized network (P<0.05, FWE corrected); B. Group comparison maps of the DMN, CEN, and SN contrasting MwoA versus HC (MwoA>HC, P<0.05, FWE corrected). Of the ICNs evaluated, intrinsic connectivity demonstrated significant differences between MwoA patients and HC. MwoA patients showed greater intra-network connectivity within the right middle frontal gyrus (rMFG) for the rCEN and left inferior frontal gyrus (lIFG) for the lCEN, and decreased intra-network connectivity within the right supplementary motor area (rSMA) for the SN. MwoA patients also demonstrated greater intrinsic DMN connectivity to the rAI and lAI, and greater intrinsic rCEN connectivity to the rAI. ICN = intrinsic connectivity network; DMN = default mode network; rCEN = right central executive network; lCEN = left central executive network; SN = salience network; rAI = right anterior insula; lAI = left anterior insula; rMFG = right middle frontal gyrus; lIFG = left inferior frontal gyrus; rSMA = right supplementary motor area; MwoA = migraines without aura; HC = healthy control; FWE = family-wise error.
Figure 2.
Correlation analysis between intrinsic connectivity abnormalities and clinical indicators of migraine.
Correlation analysis results of the greater intrinsic connectivity between both the DMN and rCEN and the rAI to duration of migraine attacks (P<0.05). The relationship between these resting-state abnormalities and the average pain intensity and attack frequency were also checked. No results exceeded the threshold. DMN = default mode network; rCEN = right central executive network; rAI = right anterior insula;