Table 1.
Main characteristics of the integrase inhibitors used in clinical practice or in clinical trials in humans.
Figure 1.
Prisma 2009 Flow diagram literature search and study selection.
PRISMA diagram showing the different steps of systematic review, starting from literature search to study selection and exclusion. At each step, the reasons for exclusion are indicated.
Figure 2.
Quality assessment of the selected studies in systematic review.
Summary of the proportion of studies that fulfilled each quality assessment criterion. When no clear answer could be obtained for a specific criterion, it was classified as “unclear”. ART = Antiretroviral Treatment.
Table 2.
Overview of studies in systematic review, grouped according to study-design and indication: regimens, population size, treatment duration and summary of main outcome data and conclusions.
Table 3.
Study characteristics of studies included in meta-analysis (n = 16): regimens, population size, timepoint of analysis and virological outcome data are enlisted.
Figure 3.
Forest Plot of mITT meta-analyses.
Panel A: Forest plot showing the meta-analysis of mITT data extracted from studies with therapy-naïve patients. Besides an overall analysis, three sub-analyses for three different comparisons are depicted. The black line indicates OR = 1, signifying no benefit of the INI arm compared to the non-INI arm. The dotted line shows the odds ratio of all included studies. The individual odds ratios as well as the proportionate weight in the overall analysis are shown in the right column. Panel B: Forest plot showing the meta-analysis of mITT data extracted from studies with ART-experienced patients in case of virological failure. Panel C: Forest plot showing the meta-analysis of mITT data extracted from studies with ART-experienced patients switching with suppressed viral load. mITT = modified intention-to-treat; ART = antiretroviral treatment; INI = integrase inhibitor; (N)NRTI = (non-)nucleoside reverse transcriptase inhibitor; PI = protease inhibitor; T20 = enfuvirtide: OR = odds ratio.