Table 1.
Basal characteristics.
Table 2.
Characteristics of the patients according to molecular status.
Figure 1.
Lung adenocarcinoma with ALK rearrangement, showing a solid growth pattern with the presence of signet ring cells in some areas (HE 40×).
FISH analysis using a break apart probe. Positive cells show a fusion of the red and green signals corresponding to the intact chromosome, and the split signals indicative of the ALK rearrangement (arrows). Immunohistochemistry for ALK in a NSCLC using D5F3 antibody. Tumor cell show cytoplasmic expression of the protein while the rest of cells are completely negative (20×).
Table 3.
Response to treatment (partial and complete) according to molecular status.
Figure 2.
Overall survival according to molecular status.
Figure 3.
Diagram of total patients and distribution according to ALK testing result for FISH and IHC.
Table 4.
Distribution of patients results according to both ALK test methods.