Figure 1.
Dichlorido(ethylenediamine)-aurate(III) ion.
Table 1.
Histological categorization of drug-induced hepatic lesions.
Figure 2.
Spectrum of renal tubular necrosis seen in acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl.
Figure 3.
Microscopic findings of renal tubules showing different grades of renal tubular necrosis as seen in the acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl.
a & b: Grade 2 as seen in H&E ×20 and ×40. Necrotic tubules are seen amongst viable renal tubules. The necrosis is less than 25% of the total material examined. In ×40 magnification, more abundant, necrotic cells are seen along with normal renal tubules. c & d: Grade 1 as seen in H&E ×40 magnification. Scattered individual apoptotic/necrotic cells with strongly eosinophilic cytoplasm and pyknotic nuclei are seen. e & f: Grade 5 as seen in H&E ×20 and ×40 The entire field shows mostly necrotic renal tubules.
Figure 4.
Renal and hepatic tissues in the controls used in acute (a,b,c) and sub-acute (d,e,f) toxicity parts of study. a:
Renal tissue showing mild congestion with no other pathological change as seen in acute toxicity controls (H&E x40). b: Hepatic tissue as seen in acute toxicity controls (H&E x40) showing mild congestion. No other pathological change is seen in this focus. c: Marked ballooning degeneration as seen in acute toxicity controls (H&E x40). d: Unremarkable renal tubules as seen in sub-acute toxicity controls (H&E x40). e: Unremarkable hepatic tissue as seen in sub-acute toxicity controls (H&E x20). f: Unremarkable hepatic tissue as seen in sub-acute toxicity controls (H&E x40).
Figure 5.
Extent of hepatic steatosis seen in acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl.
Figure 6.
Spectrum of hepatic microscopic findings as seen in the acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl.
a: Marked mixed micro and macrovesicular steatosis, H&E ×40. b & c: Marked sinusoidal congestion and dilatation, H & E ×20 and ×40 respectively. d: Marked ballooning degeneration along with two microgranulomas, H & E ×40.
Figure 7.
Microscopic pictures of renal tubules, with no evidence of necrosis as seen in sub-acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl, H&E at magnifications of : a. ×10. b. ×20. c. ×40.
Table 2.
Acute toxicity, salient hepatic microscopic findings.
Table 3.
Sub-acute toxicity, salient renal microscopic findings.
Table 4.
Sub-acute toxicity, salient hepatic microscopic findings.
Figure 8.
Hepatic microscopic findings in sub-acute toxicity study of a gold (III) compound [Au(en)Cl2]Cl. a:
Mild ballooning degeneration, H&E ×20. b: Mild ballooning degeneration, H&E × 40. c: Marked ballooning degeneration, H&E ×20. d: Marked ballooning degeneration, H&E ×40Toxicity.