Table 1.
Demographic Characteristics of AIS Patients and Controls.
Figure 1.
Levels of serum YKL-40 (A) and CRP (B) in acute ischemic stroke patients and controls.
Each box indicates the median. Horizontal lines indicate the interquartile ranges. (C) Diagnostic accuracies of serum YKL-40 and CRP for discriminating acute ischemic stroke patients (n = 100; for statistical assessment of the differences between D1 and D2, 5 of 105 patients were excluded because they [n = 5] dropped out of the D2 test) from controls (n = 34) using receiver operating characteristic (ROC) curves. Numbers in square brackets indicate diagnostic accuracies (area under the ROC curves). D1, within 12 hours of symptom onset; D2, 18–24 hours from baseline (D1); CRP, C-reactive protein. *P<0.05. aP<0.05, vs. YKL-40 on D2. bP<0.05, vs. CRP on D1. cP<0.05, vs. CRP on D2. dP<0.05, vs. YKL-40 on D1.
Figure 2.
Levels of serum YKL-40 (A) and CRP (B) depend on stroke subtype (in noncardiogenic stroke).
Each box indicates the median. Horizontal lines indicate the interquartile ranges. D1, within 12 hours of symptom onset; D2, 18–24 hours from baseline (D1); CRP, C-reactive protein; SVO, small-vessel occlusion or lacunar; LAA, large artery atherosclerosis or atherothrombosis. *P<0.05.
Table 2.
Correlation of YKL-40 and CRP Levels with Stroke Severity, Infarct volume, and Functional Outcome.
Table 3.
Multivariate-Adjusted odds ratios for Poor Functional Outcome Depend on D2 Serum YKL-40.
Figure 3.
Temporal changes in YKL-40 (A) and CRP (B) levels following acute ischemic stroke.
Open markers indicate serially analyzed protein levels in each patient. Each box indicates the median, and the closed markers indicate the interquartile ranges. D1, within 12 hours of symptom onset; D2, 18–24 hours from baseline (D1); D3, 36–48 hours from baseline; CRP, C-reactive protein. *P<0.05.