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Figure 1.

Behavioral Results.

Percentage (%) of choices in which cognitive control was selected during the free-choice period as a function of expected monetary rewards. Error bars represent one (within-subject) standard error of the mean based on Loftus and Masson [69].

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Figure 2.

Trial Structure for the fMRI Experiment.

After a variable duration fixation cross, an instruction cue signaled the currently relevant rules (profile of faces = male/female rule; book = abstract/concrete rule) and whether or not to expect a monetary reward (blue vase = no money; bills = 25¢). This was followed by a variable duration delay period and then a word or face stimulus, during which subjects made a button response. Finally, a screen revealed whether money had been earned on that trial and cumulative winnings. On key trials, a second instruction cue appeared before the stimulus. Across the two instruction cues, we varied whether there was repetition of the rules, expected reward, both, or neither.

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Figure 3.

Regions Showing Repetition Enhancement for Repetition of a Specific Rule-Outcome Pairing (Z>2.57, p<.05 FWE cluster corrected for the whole-brain).

A. Right lateral view showing regions of the LPFC exhibiting this effect. B. Activation time-course for the IFS, IFJ, and posterior DLPFC time-locked to the onset of the second instruction. The color scale denotes t-values. Nov = novel, rep = repeated. Error bars represent one (within-subject) standard error of the mean based on Loftus and Masson [69].

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Table 1.

Regions exhibiting fMRI-adaptation for repetition of rules and reward.

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Figure 4.

Regions Exhibiting Functional Connectivity with the IFS Across the Entire Time-Course (Z>2.57, p<.05 FWE cluster corrected for the whole-brain).

Rule areas (blue arrows) include bilateral lateral prefrontal cortex (LPFC), anterior mid-cingulate cortex/dorsomedial prefrontal cortex (aMCC/DMPFC), posterior middle temporal gyrus (pMTG), and intraparietal sulcus (IPS). Reward areas (red arrows) include rostral anterior and posterior cingulate cortices (rACC, PCC), orbitofrontal cortex (OFC), caudate/nucleus accumbens (NAcc), and insula. The color scale denotes t-values, and the numerical values above the images correspond to MNI coordinates. For axial and coronal slices, the right hemisphere is on the right side of the image. LH = left hemisphere, RH = right hemisphere.

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Table 2.

Regions exhibiting significant functional connectivity with the IFS.

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