Table 1.
Neurologic Function Score for boys with cALD.
Figure 1.
Boys with cALD have elevated CSF protein levels.
Total protein levels were determined in the clinical chemistry laboratory using a Kodak Ektachem method. Shown are the means ± S.D. A Student’s t-test was performed to generate the p-value.
Figure 2.
Boys with cALD have higher levels of CSF MMPs and TIMP1 than controls.
CSF MMPs and TIMPs were evaluated using a Luminex system. Statistical analysis was performed using Prism software. The data displayed are those MMPs and TIMP1 that were significantly different from the control group. The horizontal bar represents the mean.
Figure 3.
Boys with cALD have higher levels of plasma MMP9 than controls.
Plasma MMP9 was evaluated using a Luminex system as before. Statistical analysis was performed using Prism software (version 5.0d). The horizontal bar represents the mean.
Figure 4.
Levels of MMP10, TIMP1, and CSF total protein correlate with pre-HCT Loes MRI Score.
Regression analysis was performed using the previously determined MMP and TIMP1 levels and each patient’s pre-transplant Loes score. P-values and R2 were determined using Prism (version 5.0d).
Figure 5.
Levels of CSF TIMP, MMP10, and total protein correlate with neurologic score pre- and post-HSCT.
Regression analysis was performed using the previously determined MMP and TIMP levels and each patient’s pre- and post-HCT neurologic function score. The post-HSCT scores were determined at the one year post-HCT follow-up visit. P-values and R2 were determined using Prism software (version 5.0d).