Figure 1.
Schematic design of study for the multi-ethnic IBC-Lipid association meta-analysis.
The workflow includes primary analyses and secondary analyses. Details can be found in the text.
Figure 2.
Regional plots for novel lipid loci with array-wide significant regions in IBC meta-analysis of African ancestry.
A. CD36 region, B. ICAM1 region. Loci are shown as the lead SNP with a flanking region depicting the candidate gene and nearby genes included on the array. The purple diamond represents the lead SNP in the IBC meta-analysis and the dots represent the surrounding SNPs, with the different colors showing the LD relationship with the lead SNP based on YRI HapMap II information. −log10 p-values for association with HDL-C (for CD36) and TC (for ICAM1) are shown for each SNP (left-hand axis). Recombination rates in YRI HapMap II is shown in blue traces (right-hand axis).
Table 1.
Associated loci with lipid traits in individuals of African, East Asian and Hispanic ancestry.
Table 2.
Loci with significant evidence of independent lipid association signals.
Table 3.
Replication results of nine signals in 7,000 African Americans.
Table 4.
Risk score analysis of lipid profile in multiethnic populations, using weighted score of known lipid SNPs.