Figure 1.
Interconversion of cortisol and cortisone by two 11β-hydroxysteroid dehydrogenase (11β-HSD) isoforms.
11β-HSD1 catalyzes the conversion of cortisone into cortisol in the liver or fat tissues, and 11β-HSD2 catalyzes the conversion of cortisol into cortisone in kidney or colon tissues.
Figure 2.
Structures of curcumin and its pentadienone analogues.
Ar = aryl group; n = carbon numbers, where n = 0, designating open chain pentadienone compound, and n = 2, 3 designating cyclopentadienone compound.
Figure 3.
Dose-dependent inhibition on 11β-HSD1 in intact rat Leydig cells by curcumin (compound 1) and it derivatives.
Table 1.
The potency data of curcumin analogues of inhibiting 11β-hydroxysteroid dehydrogenase 1 and 2 activities.
Figure 4.
Lineweaver–Burk plot of rat liver microsomal 11β-HSD1 in the presence of compound 6.
1/V versus 1/[11DHC], V, velocity (pmol/mg protein⋅min); [11DHC], concentrations of 11DHC.
Figure 5.
Serum glucose, total cholesterol, Tg, LDL, APOA1 and APOB in rats from normal diet control (CON), HFD diet (HFD) and HFD plus curcumin (CUR).
Male rats were administered with 200 mg/kg curcumin for 2 months. Mean ± SE, n = 10. Identical letter designates no significant difference between two groups at P<0.05.