Table 1.
Characteristics of the 300 OSCC patients.
Figure 1.
Classification tree of the mtDNA geographic haplogroups observed in 300 OSCC patients.
The diagnostic variants are underlined.
Table 2.
The distribution of mtDNA haplogroups in 300 Taiwanese OSCC patients.
Figure 2.
Kaplan–Meier survival curves for OSCC patients.
A, overall survival (OS) based on mtDNA geographic haplogroups (p = 0.74). B, disease-free survival (DFS) according to mtDNA geographic haplogroups: Northeast Asia CZD haplogroup (n = 91), East Asia MGE haplogroup (n = 65), East Asia AN haplogroup (n = 25), and Southeast Asia RBF haplogroup (n = 119); p = 0.03. C, DFS according to mtDNA geographic haplogroups in patients treated with surgery alone (p = 0.008). D. DFS according to mtDNA geographic haplogroups in patients received radiotherapy after surgery (p = 0.05).
Table 3.
Associations between mtDNA geographic haplogroup and OSCC clinicopathological parameters.
Table 4.
Univariate and multivariate analysis of disease-free survival in 300 OSCC patients.
Table 5.
Characteristics of specific nonsynonymous variants in four geographic haplogroups observed in 300 OSCC patients.