Table 1.
Botanical derivation of essential oils.
Table 2.
Estimates of mean percentage activity remaining of P450 enzymes after treatment with the 13 essential oils.
Table 3.
Estimated EC50 (mg/cm2) of repellency with 95% confidence interval (CI) for the 13 essential oils.
Figure 1.
Estimated mean percentage activity remaining of P450 enzymes plotted against EC50 (mg/cm2) values of repellency.
The agreement between P450 inhibition and repellency is evident; an increase in P450 inhibition is clearly linked to an increase in repellency. Plotted values as in Tables 2 and 3.
Figure 2.
Bootstrap distribution of 10,000 correlation coefficients obtained as described in the Materials and Methods section in the text.
The exercise of determining the degree of agreement (i.e. correlation) between the P450 and the EC50 ranking systems was replicated 10,000 times to measure the variation in correlation estimates. The figure shows how the vast majority of the replicate correlation coefficients are positive, and it enables visualisation of both the value upon which the correlation coefficients are centred and the extent of their spread.