Figure 1.
The damage evident in MRI images was reconstructed for each studied patient and plotted using MRIcro software. A T1-weighted template comprising 12 axial slices was used to demarcate lesions for every patient. The colour scale indicates the percentage of overlapping lesions across patients.
Table 1.
Clinical assessment of visuospatial neglect.
Figure 2.
TBSS results in patients vs. controls: fractional anisotropy; radial diffusivity, and mean diffusivity.
(A) Red voxels represent the areas where fractional anisotropy (FA) values of patients are significantly reduced with respect to those of healthy controls, overlaid onto the group-averaged FA image. FA values are significantly reduced in the corpus callosum and its projections on the parietal white matter. (B) Blue voxels indicate the areas of increased radial diffusivity in patients. The same sections as in panel A are shown to ease the comparion with FA results. (C) Green voxels indicate tracts where MD was increased in patients. Again, the same sections as in panels A and B are shown. L = left; x,y,z, indicate the MNI coordinates.
Figure 3.
TBSS results in patients vs. controls: axial diffusivity.
Red voxels indicate tracts where axial diffusivity (Dax) was found to be increased in patients compared to healthy subjects. These results are overlaid onto the group-averaged FA image. Changes were mainly located within the corona radiata, an area of crossing fibres, where the interpretation of changes in axial and radial diffusivity can be challenging. L = left; x, y, z, indicate the MNI coordinates.
Figure 4.
Correlation between patients' FA and BIT scores.
In top panel it is illustrated the region of the posterior corpus callosum , whose fractional anisotropy (FA) value correlates with patients' performance at Behavioural Inattention test (BIT). In the bottom panel, the FA values extracted from that region are plotted, patient by patient, against their correspondent performance obtained at BIT. The post-hoc R value (Pearson correlation coefficient) was 0.91.