Figure 1.
TPN (red) and DMN (yellow) masks derived from 3vs0 contrast task-related activation and deactivation respectively of HC (corrected for multiple comparisons, p = 0.05, presented in neurological convention).
Table 1.
Sample characteristics.
Table 2.
Behavioral performance.
Table 3.
Therapeutic and sham-CPAP effects: cerebral regions showing significant task-related activation and deactivation in TPN and DMN regions on paired t-test in 1vs0, 2vs0 and 3vs0 contrasts in A) the active CPAP group and B) sham-CPAP group (MNI coordinates, corrected for multiple comparisons, p = 0.05).
Table 4.
CPAP and sham-CPAP groups compared to HC: cerebral regions showing significant task-related activation and deactivation in TPN and DMN regions in 1vs0, 2vs0 and 3vs0 contrasts in active and sham-CPAP patient' groups as compared to HC (MNI coordinates, corrected for multiple comparisons, p = 0.05).
Figure 2.
Brain regions showing significant task-related deactivation in the 0vs3-back contrast in A) 1) CPAP group at baseline AND HC (red); 2) CPAP group post-treatment AND HC (blue; purple indicates overlap between 1 and 2); and in B) sham-CPAP group at baseline AND HC (red); 2) sham-CPAP group post-treatment AND HC (blue; purple indicates overlap between 1 and 2).
Green arrows indicate increased deactivation in the tDMN after CPAP treatment (regions in blue), orange arrows indicate decreased deactivation in the tDMN after sham-CPAP treatment (regions in red) (neurological presentation, p<0.05, FDR corrected for multiple comparisons).
Figure 3.
Brain regions showing significant positive correlation between the duration of nocturnal hypoxemia and effects of task load in DMN (ie, regions where increased duration of nocturnal hypoxemia correlates with less effective deactivation of DMN regions with increasing task load; MNI coordinates, corrected for multiple comparisons, p = 0.05, neurological presentation).
Table 5.
Effects of nocturnal hypoxemia on cerebral activation in OSAS patients: cerebral regions showing significant positive correlation between the duration of nocturnal hypoxemia and effects of task load in DMN (ie, regions where increased duration of nocturnal hypoxemia correlates with less effective deactivation of DMN regions with increasing task load; MNI coordinates, corrected for multiple comparisons, p = 0.05).