Table 1.
Late toxicity grade in acutely radiosensitive (s) and non-radiosensitive (ns) patients suffering from breast cancer. Each patient is indicated with an identification number (ID).
Table 2.
Late toxicity grade in acutely radiosensitive (s) and non-radiosensitive (ns) patients suffering from head and neck cancer. Each patient is indicated with an identification number (ID).
Table 3.
Comparison between non-radiosensitive vs. radiosensitive patients for apoptosis and necrosis in each laboratory within the different dose rates.
Figure 1.
Dose-response relationship of Olive tail moment (OTM) in PBLs at different time points.
Data from two different centres E (white boxes) and D (hatched boxes) are presented. Comet assay of both laboratories revealed similar results by investigating OTM in PBLs directly after irradiation with 5 Gy and at different time points. Non-radiosensitive and radiosensitive individuals were not distinguishable.
Table 4.
Spearman rank correlation coefficient between the 2 laboratories D and E for DNA damage, assessed by the target parameters OTM and % Tail DNA standardised.
Figure 2.
Dose-response relationship of Gamma-H2AX at different time points from two different centres (white boxes – centre C, hatched boxes – centre B).
Each measured value corresponds to the n-fold change to the time point at 0 Gy after 24 hours. (a) Data for the PBLs: Box plots only include samples with an initial cell viability of higher than 80%. (b) Data for LCLs over all samples.
Table 5.
Results of the comparison between head and neck tumour (HN-Ca) and breast cancer patients (Ma-Ca) within a generalised estimating equations (GEE) analysis, adjusted for laboratory, irradiation dose and sensitivity group.
Table 6.
Required number of samples per group (radiosensitive and non-radiosensitive, respectively) to detect a significant difference between both groups (power = 80%, significance level = 5%) for a given standard deviation and effect size.