Figure 1.
A total of eight evaluations were performed. Patients were excluded for three medical reasons, including death within seven days after admission, blood transfusion and blood purification within the period of study. All enrolled patients were followed up for 28 days, and 28-day mortality was assessed as the primary outcome.
Table 1.
Subject's descriptive characteristics.
Table 2.
Outcomes after 28-day observation in two groups.
Table 3.
Receiver operating characteristic (ROC) curve analysis in prediction of mortality.
Figure 2.
The correlation analysis between baseline levels of C3 and severity scores.
(A) The relationship between C3 and APACHE II score. Data in both groups were pooled for analysis (n = 45). The linear regression indicates that the baseline levels of C3 have little correlation with APACHE II score (R2 = 0.268). (B) The relationship between C3 and SOFA score. Data in all patients were included for analysis (n = 45). The regression result shows that C3 have no correlation with SOFA score (R2 = 0.217). In addition, linear regression for each group was performed, with similar results to the pool.
Figure 3.
The observed changes of complement components in management of sepsis.
These dynamic changes were directly compared between group 1 and group 2. Plasma levels of C3 (A) and C4 (B) within 28-day observation were quite different between both groups (P<0.001). The gray area indicates the normal reference range. Data present as mean ± SD.
Figure 4.
The observed changes of infection and coagulation indexes in management of sepsis.
The values of each index were compared between group 1 and group 2. All data present as mean ± SD. CRP (A) and PCT (B) were utilized to evaluate the inflammatory response to sepsis. PT (C) and D-dimer (D) were employed to evaluate the coagulation function during sepsis. The gray area indicates the normal reference range.
Table 4.
Univariate linear regression between C3 and coagulation and infection.
Table 5.
Complement C3 depletion and sepsis outcomes.