Table 1.
Number of pregnancies classified according to screening test, gestational age when screened, and selected characteristics of the Down syndrome and unaffected pregnancies.
Figure 1.
First trimester (a) and second trimester (b) placental growth factor (PlGF) according to gestational age in Down syndrome pregnancies (circles) and medians in 2-day intervals* (a) and weekly intervals (b) in unaffected pregnancies (squares, with 95% confidence intervals) together with expected (regressed) median in unaffected pregnancies.
Figure 2.
First trimester (a) and second trimester (b) placental growth factor (PlGF) maternal weight, smoking and ethnicity adjusted MoM values according to gestational age and medians (squares, with 95% confidence intervals) in 2-day intervals* (a) and weekly intervals (b) in Down syndrome pregnancies together with expected (regressed) median.
Table 2.
Observed and regressed median PlGF MoM in Down syndrome pregnancies according to gestational age.
Table 3.
Screening performance according to detection and false-positive rates of the Combined, Quadruple and Integrated tests with and without the addition of first or second trimester placental growth factor (PlGF) according to gestational age markers are measured.
Table 4.
Screening performance according to risk cut-off of the Combined, Quadruple and Integrated tests with and without the addition of first or second trimester placental growth factor (PlGF) according to gestational age markers are measured.
Table 5.
Screening performance according to detection and false-positive rates of the Combined, Quadruple and Integrated tests with and without the addition of first trimester (11–13 weeks1) or second trimester placental growth factor (PlGF).