Figure 1.
Correlation between HCV viremia and IP-10 in serum in chimpanzees.
Box-whisker plots indicate the interquartile range and the median (horizontal line) of IP-10 concentrations in serum from animals of the different groups; “high HCV load” where the virus load of individual animal is higher as compared to median value of 200,000 IU/ml; “low HCV load” where the virus load of individual animal is lower as compared to the median value of 200,000 IU/ml; HCV resolvers and naïve, non-exposed (A). Box-whisker plots indicate the interquartile range and the median (horizontal line) of IP-10 concentrations in serum of humans and chimpanzees with high HCV load (>median virus load) and low HCV load (<median virus load) (B) and IP-10 concentrations plotted against HCV-RNA load in serum from chimpanzees and humans (C). A significant correlation between the two parameters is defined as r2>0.85 and p<0.05 where “r2” is a measure for correlation and “p” is a measure for the quality if this correlation.
Figure 2.
Relation between IP-10 levels and aminotransferases in serum.
Relation between IP-10 and liver enzymes γGT, ALT and AST from HCV-infected individual chimpanzees (A) and HCV-infected patients (B) A significant correlation between the two parameters is defined as r2>0.85 and p<0.05 where “r2” is a measure for correlation and “p” is a measure for the quality if this correlation.
Figure 3.
γGT, ALT and AST in humans and chimpanzees chronically infected with HCV.
Interquartile range and the median (horizontal line) of γGT, ALT and AST in U/ml in chimpanzees and patients chronically infected with HCV.
Table 1.
Characteristics of chimpanzee population.
Table 2.
Characteristics of the patient cohort chronically infected with HCV.