Table 1.
Summary of SEER Reported Characteristics for 169 patients with HCC.
Figure 1.
Photomicrographs of HCC tissue specimens stained using anti-CKA antibody.
Images magnified at 200×. A) Normal liver tissue demonstrates an absence of immunohistochemical staining. B) Corresponding HCC tumor specimen from the same patient demonstrates mild cytoplasmic staining of moderately-differentiated tumor cells. C) Moderately-differentiated HCC nested within an area of fibrosis. The tumor cells demonstrate moderate cytoplasmic and nuclear staining.
Table 2.
Distribution of CKA Positive Tumors in Groups Defined by Clinicopathological Variables.
Table 3.
Distribution of HK2 Positive Tumors in Groups Defined by Clinicopathological Variables.
Table 4.
Contingency Table of HK2 and CKA Expression.
Figure 2.
Patterns of overall survival (OS) based on tumor immunohistochemical expression of CKA and HK2.
Solid lines represent immunohistochemistry-positive cases while dotted lines represent immunohistochemistry-negative cases. A) OS was significantly worse for patients with CKA-positive tumors relative to patients with CKA-negative tumors (Log-Rank test p = 0.03). B) OS was also significantly worse for patients with HK2-positive tumors relative to patients with HK2-negative tumors (Log-Rank test p = 0.003). C) Among stage I and II HCC patients, OS was significantly worse for patients with CKA-positive tumors relative to patients with CKA-negative tumors (Log-rank p = 0.03). D) Among stage I and II HCC patients, OS was also significantly worse for patients with HK2-positive tumors relative to patients with HK2-negative tumors (Log-rank p = 0.02). E) Among patients with HK2-negative tumors, OS did not differ significantly on the basis of CKA expression (Log-Rank test p = 0.53). F) Among patients with HK2-positive tumors, OS was significantly worse in patients whose tumors were also CKA-positive (Log-Rank test p = 0.04). G) Among patients with CKA-negative tumors, OS did not differ significantly on the basis of HK2 expression (Log-Rank test p = 0.35). H) Among patients with CKA-positive tumors, OS was significantly worse in patients whose tumors were also HK2-positive (Log-Rank test p = 0.01).