Table 1.
Comparison of the general data for the two groups.
Figure 1.
Scores on the MCT for the two groups are shown for the five periods of life.
Figure 2.
VBM analyses showing brain areas of regional atrophy that correlate with the AbM deficit according to the score on the MCT (p<0.005, uncorrected, k = 50 voxels, including group, age, intracranial volume, and gender as nuisance covariates), with clusters including (a) left and right ventromedial, ventrolateral, orbial prefrontal cortex and anterior cingulate (BA 11/25/47), (b) left hippocampus (y = −30 to y = −40), parahippocampus (BA 36/37), retrospenial cortex (BA 30), (c) right hippocampus (y = −22 to y = −40), (d) left cingulate gyrus, (e) right insula (BA13) and superior temporal gyrus (BA22), (f) right middle occipital gyrus (BA19), (e) left precuneus (BA7).
Talairach z coordinates are indicated for each slice.
Table 2.
GM volume regions positively correlated to the score on the MCT in VBM including group, age, intracranial volume and gender as nuisance covariate, with a minimal cluster size (k) of 50 voxels and a threshold of p<.005, uncorrected.
Figure 3.
VBM analyses showing brain areas of regional atrophy that correlate with the AbM deficit according to the score on the MCT ( p<.005, uncorrected, k = 50 voxels, including group, age, intracranial volume, and gender as nuisance covariates), independently for each period of life: (A) for the ‘10–29 years’ period, (B) for the ‘30–59 years’ period, (C) for the ‘after 60 years’ period, and (D) for the “previous year".
The clusters include (a) ventro-medial, ventro-lateral, orbial prefrontal cortex +/− anterior cingulate*, (b) left hippocampus +/− parahippocampus, retrosplenial cortex and/or amygdala*, (c) right hippocampus, (d) insula and temporal neocortex, (e) occipital neocortex (precuneus not shown). Talairach z coordinates are indicated for each slice.
Figure 4.
Schematic recapitulation of the hippocampal aspects according to the period of life (p<.005, uncorrected, k = 50 voxels, including group, age, intracranial volume, and gender as nuisance covariates), including bilateral hippocampal engagement (A) for the ‘10–29 years’ period, (B) for the ‘30–59 years period, (C) for the ‘after 60 years’ period, and (D) for the ‘recent year’.
Volumes and Talairach y coordinates are indicated for each period and side (L = left, R = right; Ant. = anterior, Post. = posterior).
Table 3.
GM volume regions positively correlated to the global score on the MCT and independently for each life-period (‘0–9 years’, ‘10–29 years’, ‘30–59 years’, ‘after 60 years’, and ‘previous year’) in VBM including group, age, intracranial volume, and gender as nuisance covariates, with a minimal cluster size (k) of 50 voxels and a threshold of p<.005, uncorrected.