Figure 1.
Clinical information of the patient.
It is the typical symptom of ROU from a Chinese male patient. Ulcer is an oval, edge tidy and the glow around. This kind of Ulcer Belongs to the degree shallow of ROU.
Figure 2.
Classification tree of D5, G1, H and R complete mtDNA sequences, plus the revised rCRS.
In the classification tree the red mark showed peculiar mtDNA haplogroups (the difference of them was significant in ROU patients and healthy persons.), including haplogroups D5, G1, H and R (P<0.05 for haplogroups D5 and G1, P<0.01 for haplogroups H and R).
Table 1.
Characteristics of the study populations.
Table 2.
Haplogroups frequencies and Pearson’s chi-square and OR test in ROU patients and healthy persons.
Figure 3.
MtDNA haplogroups distribution frequency of different cohorts of ROU patients and healthy persons.
X-coordinate showed four mtDNA haplogroups, y-coordinate showed the percentage of haplogroups in the study populations. * and ** respectively showed P<0.05 and P<0.01.
Table 3.
C-stretch sequences and frequencies of mtDNA HV1, HV2 and HV3 regions in healthy persons.
Figure 4.
The sequences of mtDNA nt 16184–16193, nt 303–315 and nt 568–573.
a. The genotype was CCCCCTCCCC in nt 16184–16193. b. The genotype was CCCCCCCCTCCCCCC in 303–315. c. The genotype was CCCCCC in nt 568–573. d. The genotype was CCCCCCCTCCCCCC in 303–315.
Table 4.
C-stretch sequences and frequencies of mtDNA HV1, HV2 and HV3 regions in ROU patients.
Table 5.
The diagnostic criteria of ROU.
Table 6.
PCR primers.