Figure 1.
(A) Confidence score distribution.
Plot of the frequency of occurrence vs. the confidence scores for the interaction data used to construct the network. (B) Node degree distribution. Plot of the log10 number of nodes with a given connection vs. the log10 node degrees in the network. The relationship between node number and node degree is described by the regression equation Y = 0,3354 X−1.38 (R2 = 86.0%). (C) Bar plot of the small GTPases that have the greatest number of interactions. Interaction number is labeled above each of the columns. Columns are colored to correspond to the small GTPase subfamilies. Yellow: Rho, Red: Ras, Green: Rab, Purple: Ran, Cyan: Arf. (D) The small GTPases protein interaction network. The graph is shown as a Biolayout (Enright 2001). Color coding for the Small GTPase subfamilies is as described in panel 1C. Non GTPase nodes are colored black. Proteins/nodes are represented as circles and are sized according to the number of connections.
Figure 2.
Frequency distribution of path lengths for all interactions in the network. (B) Bottlenecks. Cartoon representation of the top 10 bottleneck proteins. Solid lines signify 1st (immediate) neighbor interactions and dotted lines represent 2nd and 3rd (nearest) neighbor interactions respectively, as labeled in the figure. (C) Network motifs. Representative clusters (1, 2, 3, 4, 5, and 10) with biological themes that were identified in the network. The highest scoring (seed) nodes in the cluster are shown as squares.
Table 1.
Clusters in the small GTPases network.