Table 1.
Demographic, clinical and MR data of the MS population.
Table 2.
Neuropsychological tests failed by cognitively impaired MS patients.
Figure 1.
LPM in cognitively impaired and cognitively preserved patients with MS.
T2-weighted lesion probability maps in cognitively impaired (upper panel, n = 36) and cognitively preserved (lower panel, n = 106) patients with MS. The color overlay created on top of the Montreal Neurological Institute standard brain shows the probability of each voxel containing a lesion in each patient group. The color bar denotes the probability range. The maximum local probability for lesions was higher in cognitively impaired patients (61% peak probability in the forceps major) than in cognitively preserved patients (37% peak probability in the posterior corona radiata). Images are shown in radiological convention.
Figure 2.
Clusters of high lesion frequency in cognitively impaired MS patients.
Yellow shows the clusters of voxels where lesions, after controlling for age and sex, were more frequent (p<0.05, corrected) in cognitively impaired (n = 36) than in cognitively preserved (n = 106) patients with MS (forceps major in A and splenium of the corpus callosum in B). Red shows the clusters of voxels that also survived correction for T2-LV (forceps major, in A). Green represents the WM fiber tract (forceps major, in A) obtained from the FSL probabilistic tractography atlas. Background image is the MNI152 standard space image. Images are shown in radiological convention.
Table 3.
White matter regions of high lesion frequency in cognitively impaired MS patients.
Table 4.
White matter regions of higher lesion frequency with lower SDMT scores.