Table 1.
Demographics and clinical characteristics of the participants.
Figure 1.
Cortical (A) and subcortical (B) GM volume loss in svMCI.
The svMCI patients showed decreased GM volume in several frontal, temporal, occipital and subcortical brain regions. For the details, see Table 2. The statistical threshold was set at P<0.01 for individual voxels and cluster size >948 mm3, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. Cortical (A) t statistical maps were rendered by using the BrainNet Viewer (http://www.nitrc.org/projects/bnv/). Subcortical (B) t statistical map was overlaid on a single anatomical image (i.e., ch2bet.nii) provided in the MRIcroN software (http://www.cabiatl.com/mricro/). R, right; L, left.
Table 2.
Regions showing GM volume atrophy in the svMCI patients.
Figure 2.
Within-group ALFF maps of the HC (left) and svMCI (right) groups.
Widely spread regions of parietal, frontal, occipital and temporal lobes exhibited high ALFF values in the both groups. Note that the posterior cingulate (PCC) and adjacent precuneus (PCu) showed the highest ALFF values in the both groups. The statistical threshold was set at P<0.001 for individual voxels and cluster size >324 mm3, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. L, left; R, right; P, posterior; A, anterior.
Figure 3.
Within-group functional connectivity maps of the HC (left) and svMCI (right) groups.
Widely spread regions of parietal, frontal, occipital and temporal lobes exhibited high functional connectivity values in the both groups. Note that the posterior cingulate (PCC) and adjacent precuneus (PCu) showed the highest functional connectivity density in the both groups. The statistical threshold was set at P<0.001 for individual voxels and cluster size >324 mm3, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. L, left; R, right; P, posterior; A, anterior.
Figure 4.
Between-group differences in the amplitude of LFO without (A) and with (B) correcting GM volume.
The svMCI patients showed decreased LFO amplitudes in frontal and temporal regions whereas increased LFO amplitudes in parietal and occipital regions. For the details, see Table 3. Of note, the between-group differences in the LFO amplitudes exhibited highly similar patterns between with and without correcting GM volume. The statistical threshold was set at P<0.01 for individual voxels and cluster size >972 mm3, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. The t statistical maps were rendered by using the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).R, right; L, left.
Table 3.
Regions showing differences in amplitudes of LFO between the svMCI patients and healthy controls.
Figure 5.
Between-group differences in functional connectivity density without (A) and with (B) correcting GM volume.
The svMCI patients showed decreased functional connectivity density in frontal, temporal and parietal regions. Of note, several brain regions which showed functional connectivity density reduction were not significant after GM correction. The statistical threshold was set at P<0.01 for individual voxels and cluster size >972 mm3, which corresponded to a corrected P<0.01 determined by Monte Carlo simulations. The t statistical maps were rendered by using the BrainNet Viewer (http://www.nitrc.org/projects/bnv/).R, right; L, left.