Figure 1.
Variation of thrombin generation in familial PC deficiency.
Thrombin generation profiles were generated from each individual’s plasma composition (n = 364), containing fII, fV, fVII, fVIII, fIX, fX, AT, TFPI and PC and a 5 pM Tf initiator. The mean thrombin curve is shown in maroon with the standard deviation in salmon. A control curve, representing mean physiologic concentrations of each factor is illustrated in gold as a comparison.
Table 1.
Plasma composition within familial PC deficiency.
Figure 2.
Investigating the range of thrombin generation within familial PC deficiency.
Individuals within the family were segregated by A) Protein C mutation, B) Prothombin G20210A polymorphism, and C) Thrombosis history. The groups with the mutation/history are shown in green (+SD) and without the mutation/history are shown in grey (–SD). A control curve, representing mean physiologic concentrations of each factor is illustrated in gold as a comparison.
Table 2.
Thrombin generation parameters within groups and stratified by gender.
Table 3.
Plasma composition comparison within groups and stratified by gender.
Figure 3.
Thrombin generation by gender.
Individuals within the family were segregated by gender for A) Protein C mutation, B) Prothrombin mutation, and C) Thrombosis history. The groups with the mutation/history are shown in green (+SD) and without the mutation/history are shown in grey (–SD) A control curve, representing mean physiologic concentrations of each factor is illustrated in gold as a comparison.
Figure 4.
Thrombin generation stratified by gender and additional risk.
Males to females with an additional category of risk were compared for either PC mutation (panels A and B), prothrombin G2010A polymorphism (panels C and D), or previous history of thrombosis (panels E and F). Female profiles are shown in pink (+SD). Male profiles are shown in blue (–SD).