Table 1.
Results of bridge IV-IA chemotherapy in retinoblastoma.
Figure 1.
Treatment flow of Bridge IV-IA chemotherapy.
Figure 2.
Two-week old female with bilateral retinoblastoma treated with bridge IV-IA chemotherapy.
Figure 2A & 2B: Fundus photographs at initial examination (2 weeks of age). 2A: right eye: large tumor with total retinal detachment. The eye was classified Reese-Ellsworth group 5A and International classification of Retinoblastoma Group D. 2B: left eye: small tumor. The eye was classified Reese-Ellsworth group 1A and International classification of Retinoblastoma Group B. Figure 2C & 2D: Fundus photographs after 4 cycles of intravenous (IV) carboplatin chemotherapy (4 months of age). 2C: right eye: the tumor has partially regressed, the retina is still totally detached and subretinal seeds are visible. 2D: left eye: complete tumor regression with laser treatment. Figure 2E & 2F: Fundus photographs at 9 months of age, after one right ophthalmic artery IA (intra-arterial) chemotherapy performed at 4 months of age. 2E: right eye: the tumor has shrunk and calcified (Type 1 regression), with disappearance of the subretinal seeds. The retina has reattached. Final electroretinogram (ERG) was fair. 2F: left eye: white scar (Type 4 regression). Final ERG was good.