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Figure 1.

Flow diagram of study selection process.

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Figure 2.

Overall quality assessment of included studies (QUADAS-2 tool).

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Table 1.

Main Characteristics of Studies Included in the Meta-analysis of Diagnosis of IA using BAL-GM.

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Figure 3.

Forest plot of sensitivities and specificities from test accuracy studies of BAL-GM in the diagnosis of IA.

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Figure 4.

SROC curve for individual studies on the accuracy of diagnosis of IA using BAL-GM.

(The correspondence between numbers and the studies can be found in supplement).

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Figure 5.

Forest plot of multiple univariable meta-regression and subgroup analyses for SEN and SPE.

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Figure 6.

Fagan plot analysis to evaluate the clinical utility of BLAF-GM test.

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Figure 7.

Funnel plot with superimposed regression line.

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Table 2.

Pooled results of the included studies for IA.

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Figure 8.

Summary ROC plot of SEN and SPE of serum GM and BAL-GM.

(Dotted ellipses around the spots represent the 95% CI around the summary estimates. The diamonds and rectangles represent individual studies and size of the diamonds/rectangles is proportional to the number of patients included in the study).

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Figure 9.

Summary ROC plot of SEN and SPE of PCR and BAL-GM.

(Dotted ellipses around the spots represent the 95% CI around the summary estimates. The circles, diamonds and rectangles represent individual studies and the size is proportional to the number of patients included in the study).

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