Figure 1.
P2RX7 gene expression in peripheral blood mononuclear cells from healthy volunteers.
P2RX7 RNA expression was increased by sleep deprivation in men (filled diamonds) and women (open triangles). Blood draw (x-axis) was at 7 p.m. and thereafter once every 6 hours. Sleep deprivation was at time points #6, #7, #8 and #9. RNA levels are the normalized average of exon expression across the entire RefSeq transcript. Diamonds and triangles indicate mean and error bars indicate SEM.
Table 1.
Clinical characteristics of the sample set that are genotyped (n = 569).
Table 2.
SNPs analyzed in P2RX7 gene.
Figure 2.
The strength of linkage disequilibrium (LD) between pairs of SNPs in ABD controls for P2RX7.
The heavy-line frame shows suggested haplotype blocks. The numbers in the squares represent the pair-wise D′ value, empty squares stand for D′ = 1. Pink-red color indicates a pair-wise LOD≥2 with redness proportional to D′. White-blue square indicates LOD<2.
Table 3.
Allelic associations for RC compared to nonRC bipolar patients and for RC compared to ABD controls in the P2RX7 gene.
Table 4.
Haplotype association for RC compared with nonRC patients and RC patients compared with blood donor controls, in the P2RX7 gene.