Table 1.
Case Definitions for Proven and Probable Invasive Candidiasis (IC).
Figure 1.
Abbreviations: RX = treatment; TX = transplant; LFTs = liver function tests; ULN = upper limit of the normal reference range; IC = invasive candidiasis; IFI = invasive fungal infection; IA = invasive aspergillosis; BDG = β-D-Glucan; medical vs. surgical = ICU location.*5 subjects in the preemptive group had a positive BDG test(s) but did not receive anidulafungin; 2 were BDG positive only at baseline/screening, 2 were transitioned to comfort care and 1 was treated empirically with antifungal therapy before development of a single positive test. All 5 subjects in the empiric therapy group that received systemic antifungal therapy had at least 1 positive BDG test around the time antifungal treatment.
Table 2.
Study Demographics*.
Table 3.
1,3-β-D Glucan (BDG) Test Characteristics.
Figure 2.
β-D-Glucan Positive Predictive Value as a function of varying Disease Prevalence.
The positive predictive value of two sequential β-D-Glucan test results ≥80 pg/ml is plotted relative to increasing invasive candidiasis prevalence. Sensitivity and specificity have been fixed at 100% and 75%, respectively.
Figure 3.
β-D-Glucan Concentrations Over Time in Subjects Receiving Preemptive versus No Antifungal Therapy.
The antifungal treatment effect on glucan concentration over time was modeled as a linear trend. Abbreviations: 0 = subjects in the standard care group with at least one positive BDG test, but no systemic antifungal treatment; 2 = subjects in active surveillance group that were treated with preemptive anidulafungin; SE = standard error of the estimated glucan concentration slope.