Table 1.
Clinical and Laboratory Characteristics of the 118 Italian Pediatric Patients with biopsy-proven NAFLD.
Table 2.
Clinical and laboratory characteristics of the 118 Italian children with NAFLD stratified by the rs35761398 CNR2 SNP encoding for the Q63R CB2 protein variant.
Figure 1.
CNR2 rs35761398 genotype and severity of liver lesions.
Relationship between the CNR2 rs35761398 genotype and the severity of A) inflammation (grades 0–2) (p = 0.0022); B) liver steatosis (grades 0–3) (p = 0.07); C) fibrosis (grades 0–3) (p = 0.24) in 118 children with NAFLD. P-values less than 0.05 have been considered statistically significant. Age, sex, waist circumference and HOMA-IR index have been used as covariates.
Figure 2.
CNR2 rs35761398 genotype and susceptibility to NASH.
A) Relationship between the CNR2 rs35761398 genotype and the presence of NASH in 118 children with NAFLD (p = 0.02). Fifty-three out of 118 patients show definitive NASH. Among these NASH subjects 2 were homozygous for the CB2 Q63 allele, 23 were CB2 Q63R heterozygous and 28 homozygous for the CB2 R63. B) Relationship between the CNR2 rs35761398 genotype and the presence of NASH in 55 I148M PNPLA3 heterozygous children with NAFLD (p = 0.001). Among I148M PNPLA3 subjects 38 out of 55 show definitive NASH and were all QR or RR for the CB2 Q63R variant. Age, sex, waist circumference and HOMA-IR index have been used as covariates.