Figure 1.
Schematic diagram of the case-cohort design in MORGAM.
Outline of the selection of individuals in the MORGAM dataset. The subcohort and all CHD cases who were genotyped (N = 4818) were chosen from the full cohort. We restricted the validation analysis to 4209 men with complete genotype data for > = 11 SNPs with the remaining SNP data multiply imputed.
Table 1.
Background characteristics of the nine cohorts.
Table 2.
Association between SNPs and coronary heart disease.
Table 3.
Comparison of models with and without genetic risk scores.
Table 4.
Association between LPA haplotypes and CHD in MORGAM.
Table 5.
Addition of family history information to genetic risk scores.
Figure 2.
Kaplan-Meier curves may better predict those with premature CHD.
Survival curves assessing the time to incident CHD with increasing age across four GRS categories for GRS1 (A) and GRS2 (B). Survival probabilities are truncated from 0–0.4.