Table 1.
Thyroid profile before (Day 1) and after (Day 4) 3 days of T4 supplementation (mean ± SD).
Table 2.
Metabolic rate (RMR), respiratory quotient (RQ) and vital signs during rest before (Day 1) and after (Day 4) 3 days of T4 treatment (mean ± SD).
Table 3.
Exercise metabolic data before and after 3 days of T4 treatment (mean ± SD).
Figure 1.
State 3 and state 4 respiration and FCCP-induced maximal respiration of mitochondria isolated from the vastus lateralis before and after 3 days of T4 treatment (n = 8).
State 3, or ADP-stimulated respiration was decreased (p = 0.057) with no change in state 4 (leak-dependent) respiration (p = 0.37). Maximal respiration induced by the addition of the uncoupler FCCP also tended to decrease with T4 treatment (p = 0.07).
Figure 2.
Relationship between the change in resting metabolic rate and the change in free T4 after 3 days of T4 treatment, after controlling for baseline free T4 levels.
r = 0.61, p = 0.06.
Figure 3.
Experimental protocol and timeline of testing procedures.