Figure 1.
Effect of iontophoresis of bosentan 10
−2 M, sitaxentan 10 −2 M and NaCl 0.9 % on skin blood flux in rats, expressed as mean (± SEM) percentage change from baseline (%BL), in the cathodal direction (Fig. 1A) and the anodal direction (Fig. 2B).
Table 1.
Effect of cathodal and anodal iontophoresis of bosentan and sitaxentan on skin blood flux recorded on the back and the hind legs of rats.
Figure 2.
Typical tracing of the effect of i.a. endothelin 0.5 10−5 M on arterial pressure in rats: the initial transient decrease of arterial pressure is followed by a sustained increase (Fig 2A).
Mean (± SEM) arterial pressure during i.a. endothelin perfusion and iontophoresis of bosentan or sitaxentan in the cathodal (blue line) and anodal (red line) directions in rats (Fig. 2B).
Table 2.
Effect of cathodal and anodal iontophoresis of bosentan and sitaxentan on skin blood flux recorded on the back and the hind legs of rats during endothelin infusion.
Figure 3.
Effect of iontophoresis of bosentan 10
−2 M, sitaxentan 10 −2 M and NaCl 0.9% on skin blood flux during infusion of i.a. endothelin 0.5 10 −5 M in rats, expressed as arbitrary perfusion units mean (mean±SEM), in the cathodal direction ( Fig 3A ) and anodal direction (Fig. 3B).
Figure 4.
Effect of iontophoresis of sitaxentan 10
−2 M (red lines) and NaCl 0.9 % (blue lines) on skin blood flux, expressed as a percentage change from baseline (%BL), in the forearm skin of five healthy volunteers. Current intensity was set at 20 µA (dashed lines) or 100 µA (solid lines).