Figure 1.
Flow Diagram of This Study.
Figure 2.
Trust Game Structure.
Table 1.
Behavior in Trust Game, and Effects of Minocycline on Personality, Anxiety and Trust.
Table 2.
Multiple Regression Analysis on Behavior in Trust Game.
Figure 3.
Possible Impact of Microglia on Personality and Social Behaviors.
Early-life environmental experiences such as psychological stress and traumatic events may activate human microglia, establish a certain neuro-synaptic-microglial connection, which is memorized unconsciously as a primer for an extended period, and this formation in the human brain determines each human’s personality and personality- oriented social behaviors in later life. In sum, neuronal networks with active microglia may induce noisy-decision-making, which is equivalent to personality- oriented behaviors (A). On the other hand, decision-making with neuronal dominant networks may induce straightforward behaviors, which are less affected by personality (B). In the present study, the control group’s personality- oriented behaviors could be formulated by microglial priming effects (A), and the minocycline group’s situation- oriented behaviors may be induced by suppressing microglial contribution to social behaviors (B).