Table 1.
Mapping of candidate oxidative-stress genes to molecular pathways of interest.
Table 2.
Distribution of main characteristics by smoking status at follow-up and PM10 exposure during follow-up (N = 6501).
Table 3.
Nominally significant gene-environment interactions by outcome and exposure.
Figure 1.
Distribution of interaction p-values across genes mapping to pathways with weak interaction signals.
P-values of interaction on the gene-level are given on a minus log10 scale (y-axis), i.e. higher bars represent smaller interaction p-values. (A) Genes of the mitochondrial dysfunction pathway interacting with PM10 and packyears exposure between surveys on FEV1/FVC decline. (B) Genes of the methane metabolism pathway interacting with PM10 and packyears exposure between surveys on FEF25–75 decline. (C) Genes of the apoptosis signaling pathway interacting with PM10 and packyears exposure between surveys on FEV1 decline.
Table 4.
Effect estimates of the strongest interacting SNP from each nominally significant gene on FEV1/FVC decline (n = 650).
Table 5.
rs2035268 genotype specific estimates of the effect of interval PM10 and pack years exposure on percentage decline in FEV1/FVC ratio during 11 years of follow-up.