Figure 1.
Example fundus images of stages of AMD. Top left: Stage 0, top right: Stage 1, middle left: Stage 2, middle right: Stage 3, bottom left: Stage 4 atrophic AMD, bottom right: Stage 4 neovascular AMD.
Table 1.
Definitions of the Mutually Exclusive Stages of AMD.
Figure 2.
Boxplots representing the change in the visual field with stage of severity of disease.
The change in MD (dB), PSD (dB), LSV and number of PD defects as a function of stage of severity of disease, for standard automated perimetry (SAP) and short-wavelength automated perimetry (SWAP) is shown. Boxplot limits represent the 15th, 25th, 50th, 75th and 85th percentiles.
Table 2.
Summary table of global indices as a function of stage of severity of AMD.
Table 3.
Kruskal-Wallis test of significant variation in visual field measures with advancing stage of AMD.
Table 4.
Post hoc analyses (Mann-Whitney U test with Bonferroni adjustment) to detect significant differences in visual field measures between AMD stages and normal.
Figure 3.
(%) map for SAP and SWAP. Mean coefficients of variation for the AMD patients and normal subjects are shown. Maps are displayed as a right eye.
Figure 4.
Frequency of defect maps show the % of eyes at each stimulus location which have significant defects on PD analysis for SAP and SWAP as a function of stage of disease. Maps are displayed as a right eye.
Figure 5.
Top: Sector arrangement of the 10–2 stimulus locations. Middle: The group mean MD in each sector for SAP and SWAP for normal and AMD subjects is displayed. Bottom: The scatterplot of MD as a function of stage of AMD shows the slope of univariate linear regression (dB per stage), in each sector for SAP and SWAP.
Figure 6.
Calculation of Severity Index and change in Severity Index with stage of AMD.
Based on Pattern Deviation (PD) maps, visual field sectors were weighted whereby the greatest weight corresponded to the central sector (Spatial Location Weight). This was then multiplied by a depth defect score according to the PD probability value (Pattern Deviation Weight). Middle, box: Example calculation: the sum was then divided by the maximum possible score to give the Severity Index ranging between 0 and 1, where 0 indicates no field loss and 1 indicates maximum defects across the entire field. Bottom: Boxplots representing the change in Severity Index as a function of stage of severity of disease, for standard perimetry (SAP) and short-wavelength automated perimetry (SWAP). Boxplot limits represent the 15th, 25th, 50th, 75th and 85th percentiles.
Figure 7.
Boxplots representing the change in visual acuity with stage of severity of disease.
The change in visual acuity (logMAR) as a function of stage of severity of disease and post hoc analyses (Mann-Whitney U test with Bonferroni adjustment) to detect significant differences in visual acuities between AMD stages and normal are shown. Boxplot limits represent the 15th, 25th, 50th, 75th and 85th percentiles. Significant differences in the posthoc analyses are the p-values in bold and have a conservative Bonferroni adjustment for multiple comparisons.