Figure 1.
Two stage study design with inclusion and exclusion criteria of cases and selection of gene candidates.
Table 1.
Characteristics of papillary thyroid cancer cases from the Ukrainian-American study cohort, 1998–2008.
Table 2.
Summary statistics for genes with significant differential dose-expression relationship based on qRT-PCR measurements.
Figure 2.
Residual gene expression by tissue type in relation to I-131 thyroid dose estimates.
Note: Mean of residual gene expression after removing the effects of age, oblast, and sex is plotted separately for normal tissue (left part of the graph) and tumor tissue (right part of the graph) against the mean of three I-131 dose categories (0.11, 0.57, 2.62 Gy). Circles with grey fills correspond to mean gene expression values for normal tissue and squares with black fills correspond to mean gene expression values for tumor tissue. Error bars represent 95% confidence intervals. P-values for association with dose are based on a 2 degree of freedom test and a 1 degree of freedom trend test, respectively, and given separately for normal and tumor tissue in the bottom of each panel.
Figure 3.
Residual gene expression by tissue type in relation to I-131 thyroid dose estimates.
Note: Mean of residual gene expression after removing the effects of age, oblast, and sex is plotted separately for normal tissue (left part of the graph) and tumor tissue (right part of the graph) against the mean of three I-131 dose categories (0.11, 0.57, 2.62 Gy). Circles with grey fills correspond to mean gene expression values for normal tissue and squares with black fills correspond to mean gene expression values for tumor tissue. Error bars represent 95% confidence intervals. P-values for association with dose are based on a 2 degree of freedom test and a 1 degree of freedom trend test, respectively, and given separately for normal and tumor tissue in the bottom of each panel.