Figure 1.
The CNR1 gene: chromosomal location, tagSNPs, haplotype structure and alleles.
*The CNR1 gene locus covers ∼15 kb on Chromosome 6 (chromosome 6 is shown in the reverse orientation, with arm q on the left). Six haplotype tagging SNPs were genotyped, based upon our prior work [25], and reference sequence numbers for the tag SNPs are presented. These SNPs are inherited in combination (haplotypes).
Table 1.
Baseline characteristics of study subjects (n = 590).
Table 2.
Effect of haplotype on triglycerides, LDL-cholesterol and HDL-cholesterol in 411 normal to overweight males (Cohort #1) on eucaloric diets.
Figure 2.
Effect of H3 haplotype on serum HDL-cholesterol levels in women.
Values shown are mean+standard error. In normal to overweight females, changing from low fat (LF) to high fat (HF) diet increased HDL-C from 49.0±8.0 mg/dl to 62.8±11.2 mg/dl in H3 haplotype carriers and from 49.8±10.9 mg/dl to 57.7±10.9 mg/dl in H3 non-carriers. In obese females, calorically restricted (−15% kcal) HF diet increased HDL-C from 50.11±11.60 mg/dl to 52.29±10.38 mg/dl in H3 haplotype carriers and decreased HDL-C from 47.99±12.90 mg/dl to 45.49±8.95 mg/dl in H3 non-carriers.
Table 3.
Effect of haplotype on triglycerides, LDL-cholesterol and HDL-cholesterol in 71 normal to overweight females (cohort #2) on eucaloric diet.
Table 4.
Effect of haplotype on triglycerides, LDL-cholesterol and HDL-cholesterol in 108 obese females (cohort #3) on calorie restricted diet.a