Figure 1.
Directed acyclic graph (DAG) representing conditional independencies (by the absence of arrows) between the genetic instrument Z, the risk factor X, the outcome Y and the confounders U.
Table 1.
Allocation of the n individuals of a sample according to Z, X and Y.
Table 2.
Summary results of 2000 simulations under various situations for each of the five methods.
Figure 2.
IQR of the log odds-ratios estimated from 2000 simulations under various situations for each of the five methods in function of the proportion of compliers .
IQR of estimates (dashed-dotted line),
(dashed line),
(dotted line) and
(solid line) have been divided by the IQR of estimate
. The sample size is
.
Figure 3.
Boxplots of the log odds-ratios estimated from 2000 simulations under various situations for each of the five methods (from left to right: ,
,
,
,
).
The sample size is and the proportion of compliers is
. The horizontal dashed line represents the true log odds-ratio.
Table 3.
Allocation of the individuals of our example according to Z, X and Y.