Figure 1.
The probabilistic atlas of the CC divided in eight portions.
CC1: orbital frontal, CC2: anterior frontal, CC3: superior frontal, CC4: superior parietal, CC5: posterior parietal, CC6L: left temporal, CC6R: right temporal, CC7: occipital. In the center, the CC tractographic reconstruction of one healthy subject, to better show the location of the eight portions.
Figure 2.
In blue, voxels with pcorr<0.05 are highlighted. a) Comparison HC vs. aMCI; b) Comparison AD vs. aMCI; c) Comparison HC vs. AD. As highlighted by the red circles, in the comparisons a) and c) the FA of the whole CC resulted significantly reduced in AD and aMCI with respect to HC. In case b), instead, FA results significantly reduced in AD compared to aMCI only in the frontal CC regions (CC1–CC2–CC3).
Table 1.
Demographic information of the sample.
Table 2.
Results of the atlas-based analysis.
Table 3.
Results of the skeleton-based analysis of the CC.
Table 4.
Comparison between atlas-based tractography and TBSS in terms of overall percentage of correct pathology detection, sensitivity and specificity.
Table 5.
80/20% Cross-validation of the logistic regression model.